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目的对使用改良后的微波(MW)消融与射频(RF)消融在活体猪肝脏和小肝癌(SHCC)病人中的前瞻性比较。方法在动物实验中,使用水冷轴探针或内部冷却电极在活体猪肝脏进行MW和RF消融。对两种消融方法的消融直径进行了比较。在临床研究中,42例小肝癌病人采用MW或RF治疗,在完全消融(CA)和肿瘤局部进展(LTP)方面进行了比较。结果 MW消融和RF消融在猪的肝脏和小肝癌的消融量分别为(33.3±15.6)cm3和(18.9±9.1)cm3、(109.3±58.3)cm3和(48.7±30.5)cm3,MW消融的消融范围更显著。MW消融和RF消融的CA率分别为95.5%(21/22)和95.0%(19/20)。在5.1个月的随访中,LTP率在MW消融组为18.2%(4/22),在RF消融组为15.0%(3/20)。结果使用改良后的MW消融比RF消融产生更大的消融范围,并且在肿瘤局部控制方面与射频消融疗效相似。MW消融对于治疗小肝癌是一种安全和前景良好的治疗方法。
A prospective prospective comparison of modified microwave ablation and radiofrequency ablation in live pig liver and small hepatocellular carcinoma (SHCC) patients. Methods In animal experiments, MW and RF ablation were performed in live pig livers using water-cooled shaft probes or internal cooling electrodes. The ablation diameters of the two ablation methods were compared. In a clinical study of 42 patients with small hepatocellular carcinoma treated with MW or RF, a comparison was made between complete ablation (CA) and local tumor progression (LTP). Results The ablation volume of MW ablation and RF ablation were (33.3 ± 15.6) cm3 and (18.9 ± 9.1) cm3, (109.3 ± 58.3) cm3 and (48.7 ± 30.5) cm3 respectively in MW and ablation of MW ablation The range is more pronounced. The CA rates for MW ablation and RF ablation were 95.5% (21/22) and 95.0% (19/20), respectively. At 5.1 months of follow-up, LTP rates were 18.2% (4/22) in the MW ablation group and 15.0% (3/20) in the RF ablation group. Results Using modified MW ablation resulted in a greater ablation range than RF ablation and similar efficacy to radiofrequency ablation in local tumor control. MW ablation for the treatment of small liver cancer is a safe and promising treatment.