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目的:观察奈达铂(NDP)联合氟尿嘧啶(5-FU)治疗晚期鼻咽癌的近期疗效和安全性。方法:将我院2005年-2011年42例晚期鼻咽癌患者随机均分为治疗组和对照组,治疗组采用NDP80～100mg·m-2,静脉滴注,d1;5-FU600mg·m-2,d1～5。对照组采用顺铂(CDDP)30mg·m-2,静脉滴注,d1～3;5-FU600mg·m-2,d1～5。2组均3周为1个周期,治疗2个周期后评价近期疗效及不良反应。结果:治疗组与对照组的有效率分别为61.90%和38.10%,治疗组明显优于对照组,差异有统计学意义(P<0.05)。与对照组比较,治疗组消化道不良反应、肝肾毒性轻微,差异有统计学意义(P<0.05)。结论:NDP联合5-FU治疗晚期鼻咽癌近期疗效及安全性较好。
Objective: To observe the short-term efficacy and safety of NDP combined with 5-fluorouracil in the treatment of advanced nasopharyngeal carcinoma. Methods: Forty-two patients with advanced nasopharyngeal carcinoma in our hospital from 2005 to 2011 were randomly divided into treatment group and control group. The treatment group was treated with NDP80-100 mg · m-2, intravenous drip, d1, 5-FU600mg · m- 2, d1 ~ 5. The control group was given cisplatin (CDDP) 30mg · m-2, intravenous drip, d1 ~ 3; 5-FU600mg · m-2, d1 ~ 5.2 group were 3 cycles of 1 cycle, after 2 cycles of evaluation Recent effects and adverse reactions. Results: The effective rates of the treatment group and the control group were 61.90% and 38.10%, respectively, which were significantly better in the treatment group than in the control group (P <0.05). Compared with the control group, the adverse reactions of digestive tract in the treatment group were mild with liver and kidney toxicity, the difference was statistically significant (P <0.05). Conclusion: NDP combined with 5-FU in the treatment of advanced nasopharyngeal carcinoma has short-term curative effect and safety.