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目的:探讨临床使用葛根素注射剂发生不良反应的可疑影响因素。方法:通过检索2003—2012年某省不良反应中心葛根素注射剂所致不良反应报告1 016例,对患者使用葛根素注射剂的临床特点及葛根素注射剂的不良反应相关因素进行统计分析,采用SPSS13.0软件对葛根素注射剂不良反应的影响因素进行Logistic回归分析。结果:葛根素注射剂不良反应的主要影响因素有:患者性别、年龄、过敏史、剂型、剂量、用药天数。其不良反应主要为皮肤系统,其次为消化系统。结论:在葛根素注射剂使用过程中,应做到用药前仔细询问患者既往过敏史和用药史,根据患者体质,辨证个体化谨慎用药,同时对患者进行用药教育,加强用药监护,从而减少其不良反应的发生。
Objective: To investigate the suspicious influencing factors of adverse reactions in clinical use of puerarin injection. Methods: A total of 1 016 cases of adverse reactions induced by puerarin injection in a province from 2003 to 2012 were retrospectively analyzed. The clinical features of puerarin injection and the related factors of adverse reactions of puerarin injection were analyzed statistically by SPSS13. 0 Software Logistic regression analysis of the influencing factors of adverse reactions of puerarin injection. Results: The main influencing factors of adverse reactions of puerarin injection were the patient’s gender, age, history of allergy, dosage form, dosage and medication days. The main adverse reactions of the skin system, followed by the digestive system. Conclusion: During the use of puerarin injection, patients should be asked carefully before treatment history of allergies and history of medication, according to the patient’s physique, dialectical discretion medication, at the same time medication education for patients to strengthen the medication monitoring, thereby reducing its adverse The reaction occurred.