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本文对正常人体内静脉注射信法丁的药物动力学和药效学进行了研究。结果表明,药物动力学符合二室开放模型,终端消除半衰期3.16 h;表观分布容积99.40 L;总体清除率392 ml/min;药时曲线下面积1057 h·ng/ml;胃液pH、胃液分泌量和胃酸分泌量等药效学指标测定表明,单剂量静注信法丁20 mg,体内有效作用时间可持续8～9 h,以Hill作图法描述了血药浓度与药效学(胃酸抑制率)的关系,推导出描述血药浓度与药效的关系式为:E=100·C~(2.60)/(C~(2.60)+14.71~(2.60)),用此数学模型可以由血药浓度预测药效,或由药效预测血药浓度。
This article studies the pharmacokinetics and pharmacodynamics of intravenous xinfadin in normal people. The results showed that the pharmacokinetics was in accordance with the two-compartment open model, and the terminal elimination half-life was 3.16 h. The apparent volume of distribution was 99.40 L. The overall clearance rate was 392 ml / min. The area under the curve was 1057 h · ng / ml. Amount and gastric acid secretion and other pharmacodynamic indicators measured showed that a single dose of intravenous infusion of Ding 20 mg, the effective duration of action in vivo sustainable 8 ~ 9 h, Hill mapping method described the blood concentration and pharmacodynamics (acid Inhibition ratio), the relationship between plasma concentration and drug efficacy was deduced: E = 100 · C ~ (2.60) / (C ~ (2.60) + 14.71 ~ (2.60)). Using this mathematical model, Predict the efficacy of blood concentration, or predict the blood concentration by pharmacodynamics.