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锂盐是一种抗精神病的药物,常用于情感性精神疾患的治疗和预防,但其作用机制仍未阐明。已知,中枢性多巴胺能神经元是抗精神药物以及一些中枢激动剂的作用点。我们应用萤光分光光度法测定了大鼠腹腔内注射锂盐1、3和5天后不同脑区内多巴胺的含量。实验结果表明注射锂盐24小时后,大鼠脑和脊髓内多巴胺含量是降低的;注射锂盐3天和5天后,相应出现多巴胺含量的轻度升高和显著升高。这就说明在锂盐作用下,动物中枢性多巴胺能神经元发生了一系列代谢性变化。有关锂盐对脑内多巴胺代谢的影响尚无一致意见。我们根据实验结果作了初步的探讨
Lithium salt is an anti-psychotic drug, commonly used in the treatment and prevention of emotional mental disorders, but its mechanism of action is still not elucidated. It is known that central dopaminergic neurons are the point of action of antipsychotics as well as some central agonists. Fluorescence spectrophotometry was used to determine the content of dopamine in different brain regions of rats after 1, 3 and 5 days of intraperitoneal injection of lithium salt. The experimental results showed that the content of dopamine in the brain and spinal cord of rats decreased after 24 hours of injection of lithium salt. After 3 days and 5 days of injection of lithium salt, correspondingly, mild increase and significant increase of dopamine content appeared. This shows that under the action of lithium salt, a series of metabolic changes occur in central nervous dopaminergic neurons in animals. There is no consensus on the effect of lithium on dopamine metabolism in the brain. Based on the experimental results we made a preliminary discussion