美国药典和美国副药典测定片剂、胶囊或酏剂中的巴比妥类是采用重量法,分光光度法和滴定测定法。作者认为这些化合物结构相似,大多数仅是第5位取代基不同,用同一方法测定是有利的。本文采用柱分配层析法测定速可巴比妥、异戊巴比妥和戍巴比妥。该法以巴比妥酸盐的溶液为固定相,用乙醚-异辛烷(1:9)洗脱,并通过 K_3PO_4柱,使巴比妥酸盐留在柱上而其他物质被冼脱掉,再用乙醚-异 The United States Pharmacopoeia and the U.S. Paratyphus determine the presence of barbiturates in tablets, capsules or elixirs using gravimetric, spectrophotometric and titration methods. The authors believe that these compounds are structurally similar, most of them differ only in the 5th substituent, which is advantageous in the same way. In this paper, column distribution chromatography was used to determine abciximab, pentobarbital and pentobarbital. The method using barbituronate solution as the stationary phase, with ether - isooctane (1: 9) elution, and through the K_3PO_4 column, leaving barbiturates in the column while the other substances were removed Xian , Then ether - different