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目的:探讨前列地尔治疗慢性肾功能衰竭患者的临床效果。方法:选取2014年6月至2016年6月贵州医科大学第三附属医院收治62例慢性肾功能衰竭患者为研究对象,随机平均分为观察组与对照组,两组患者均行常规综合治疗,观察组在此基础上加用前列地尔治疗,观察患者肾功能指标、24 h尿蛋白定量,空腹彩超观察患者肾动脉内径(D),计算阻力指数(RI),并观察患者治疗不良反应。结果:经治疗,两组患者肾功能指标与24 h尿蛋白定量均得到显著改善,观察组治疗后肾功能指标与24 h尿蛋白定量、肾血流动力学指标显著优于对照组,差异具有统计学意义(P<0.05);对照组无患者出现不良反应,观察组在静脉滴注前列地尔注射液的过程中,2例患者出现血管红肿的情况,1例患者出现头晕症状,将滴注速度减慢后患者症状均得以缓解,未对整体治疗产生影响。结论:前列地尔治疗慢性肾功能衰竭患者的疗效显著,安全性高,具有极高的临床应用价值。
Objective: To investigate the clinical effect of alprostadil in patients with chronic renal failure. Methods: Sixty-two patients with chronic renal failure admitted to the Third Affiliated Hospital of Guizhou Medical University from June 2014 to June 2016 were randomly divided into observation group and control group. Both groups were treated with conventional comprehensive treatment, On the basis of this observation, the observation group was given alprostadil treatment, and the indexes of renal function, 24-hour urinary protein and intra-abdominal ultrasound were used to observe the diameter of renal artery (D), calculate the resistance index (RI) and observe the adverse reactions. Results: After treatment, the indexes of renal function and 24 h urinary protein in both groups were significantly improved. The indexes of renal function and 24 h urinary protein in the observation group after treatment were significantly better than those in the control group (P <0.05). There were no adverse reactions in the control group. During the intravenous infusion of alprostadil in the observation group, 2 cases showed vascular swelling and 1 case had dizziness. Symptoms were relieved after slowing down and did not affect the overall treatment. Conclusion: Alprostadil is effective in treating chronic renal failure patients with high safety and high clinical value.