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目的探讨荊花胃康联合乌司他丁治疗老年胃溃疡伴早期胃癌患者生存质量的影响。方法选取胃溃疡伴早期胃癌患者68例,按随机数字法分为观察组和对照组,每组34例。对照组给予乌司他丁1×10~5U静脉推注,3次/d,观察组在对照组的基础上加用荆花胃康160 mg,3次/d,餐前口服。结果两组患者白细胞介素(IL)-6、肿瘤坏死因子(TNF)-α等炎症因子及C反应蛋白(CRP)水平在治疗后7、14、21 d均较治疗前明显降低(P<0.05),并且观察组各指标水平明显低于对照组(P<0.05)。观察组治疗总有效率97.06%,明显高于对照组(76.47%,P<0.05)。结论联合使用荆花胃康与乌司他丁可减轻炎症因子的表达,促进胃溃疡的愈合,对老年胃癌患者胃黏膜具有一定的保护作用,改善患者的生活质量。
Objective To investigate the effects of Jinghua Weikang combined with ulinastatin on the quality of life of elderly patients with gastric ulcer and early gastric cancer. Methods Sixty-eight patients with gastric ulcer and early gastric cancer were selected and randomly divided into observation group and control group with 34 cases in each group. Control group was given ulinastatin 1 × 10 ~ 5U intravenous bolus, 3 times / d, the observation group in the control group based on the use of Jinghuaweikang 160 mg, 3 times / d, before meals. Results The levels of inflammatory cytokines such as interleukin (IL) -6 and tumor necrosis factor (TNF) -α and C-reactive protein (CRP) in the two groups were significantly decreased at 7, 14 and 21 days after treatment (P < 0.05), and the indicators of the observation group were significantly lower than the control group (P <0.05). The total effective rate of observation group was 97.06%, which was significantly higher than that of control group (76.47%, P <0.05). Conclusion The combination of Jinghuaweikang and ulinastatin can reduce the expression of inflammatory factors, promote the healing of gastric ulcer, and have certain protective effect on gastric mucosa in elderly patients with gastric cancer and improve the quality of life of patients.