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目的观察针刺与氟尿嘧啶、益气解毒中药复方联合应用对荷瘤小鼠肿瘤细胞的抑制性作用。方法制备小鼠肝癌H22细胞实体瘤模型,分成肝癌模型组、化疗药物组(氟尿嘧啶腹腔注射)、益气解毒方组(中药灌胃)、针刺大椎穴组、化疗药物+针刺大椎穴组、益气解毒方+针刺大椎穴组,并与正常小鼠进行对照。观察荷瘤小鼠一般生存状态,并计算各组肿瘤抑制率。结果化疗药物组小鼠一般状态较差,益气解毒方组及针刺组一般状态均优于化疗药物组,针药联用组小鼠的一般生存状态优于模型组与单一疗法组;各实验组对肿瘤均有明显抑制作用(P<0.01)。结论针刺联合药物对小鼠肿瘤细胞的生长具有较好的抑制作用。
Objective To observe the inhibitory effect of combination therapy of acupuncture with fluorouracil and Yiqi Jiedu compound on tumor cells of tumor-bearing mice. Methods The model of hepatocellular carcinoma H22 cells was established and divided into three groups: model group of hepatocarcinoma, chemotherapy group (intraperitoneal injection of fluorouracil), Yiqi Jiedu Decoction (group of traditional Chinese medicine), acupuncture at Dazu acupoint group, chemotherapy drug + acupuncture at Dazu acupoint group , Yiqi Jiedu side + acupuncture Dazhui acupuncture group, and compared with normal mice. The tumor-bearing mice were observed for their general survival status and tumor inhibition rates were calculated. Results The general state of chemotherapy drug group mice was poor, the general state of Yiqi Jiedu Fang and acupuncture group was better than chemotherapy group, and the general survival state of mice in acupuncture and medicine group was better than that of model group and monotherapy group. The experimental group significantly inhibited the tumor (P <0.01). Conclusion Acupuncture combined with drugs has a good inhibitory effect on the growth of mouse tumor cells.