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实验证明标记物[~(14)C]碳酸氢钠、[5-~3H]乳清酸和[5-~3H]尿嘧啶都能掺入日木血吸虫虫体,并进入核酸。匀浆的酶活力测定,证明了虫体存在嘧啶自身合成途径的酶系:氨甲酰磷酸合成酶Ⅱ-氯甲酰天冬氨酸转移酶(ATCase)-二氢乳清酸酶酶组,二氢乳清酸脱氢酶(DHOdehase)以及乳清酸磷酸核糖转移酶(OPRTase)-乳清酸核苷-5′-磷酸脱羧酸酶(ODCase)组。虫体还存在补救途径的酶。对这两条途径在虫体嘧啶合成代谢中的重要性进行了讨论。感染日本血吸虫病的小鼠口服硝唑咪和硝硫氰胺后,对血吸虫的乳清酸磷酸核糖转移酶-乳清酸核苷-5′-磷酸脱羧酶有一定的抑制作用,该酶组有可能作为抗血吸虫药物的攻击点。
Experiments show that the labeled [~ (14) C] sodium bicarbonate, [5- ~ 3H] orotic acid and [5- ~ 3H] uracil can be mixed into S. japonicum and enter the nucleic acid. Homogenate enzymatic activity was measured to prove the presence of pyrimidine self-synthesis pathway enzymes: carbamoyl-phosphate synthetase Ⅱ-ascorbyl-aspartate aminotransferase (ATCase) -hydroxylases enzyme group, DHOdehase and OPRTase-orotidine-5’-phosphate decarboxylase (ODCase) groups. Insects also exist remedial pathway enzymes. The importance of these two pathways in pyrimidine pyrimidine biosynthesis is discussed. In mice infected with Schistosoma japonicum, oral administration of nitazoxanide and nitrocytamine inhibited the orotic acid phosphotransferase-orotidine-5’-phosphate decarboxylase of Schistosoma japonicum to a certain extent. The enzyme group It is possible as an anti-schistosome drug attack point.