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Chemokines are a superfamily of small proteins that bind to G protein-coupled receptors on target cells andwere originally discovered as mediators of directional migration of immune cells to sites of inflammation andinjury.In recent years,it has become clear that the function of chemokines extends well beyond the role inleukocyte chemotaxis.They participate in organ development,angiogenesis/angiostasis,leukocyte traffickingand homing,tumorigenesis and metastasis,as well as in immune responses to microbial infection.Therefore,chemokines and their receptors are important targets for modulation of host responses in pathophysiologicaiconditions and for therapeutic intervention of human diseases.Cellular & Molecular Immunology.2004;1(2):95-104.
Chemokines are a superfamily of small proteins that bind to G protein-coupled receptors on target cells and have originally discovered as mediators of directional migration of immune cells to sites of inflammation and in jury. Recent years, it has become clear that the function of chemokines extends well beyond the role inleukocyte chemotaxis. the participation in organ development, angiogenesis / angiostasis, leukocyte trafficking and homing, tumorigenesis and metastasis, as well as in immune responses to microbial infection. ago chemokines and their receptors are important targets for modulation of host responses in pathophysiology studies and for therapeutic intervention of human diseases. Cellular & Molecular Immunology. 2004; 1 (2): 95-104.