过氧化物酶体增殖物激活受体γ(PPARγ)是配体活化的核转录因子,属核受体超家族成员。目前研究发现其在脑缺氧缺血性疾病中有对抗炎症介质、抗脂质过氧化反应、对抗神经元的兴奋性毒性等作用。因此,对其及配体在脑缺血缺氧性疾病中进行作用机制的研究,可能有助于对脑缺血缺氧性疾病预防或治疗中起作用的新药物靶位点的发现。 Peroxisome proliferator-activated receptor γ (PPARγ) is a ligand-activated nuclear transcription factor, a member of the nuclear receptor superfamily. The current study found that in brain hypoxic-ischemic disease have anti-inflammatory mediators, anti-lipid peroxidation, antagonistic neuronal excitotoxicity and so on. Therefore, the study of the mechanism of action of ligand and its ligand in cerebral ischemia-hypoxic disease may contribute to the discovery of new drug target sites that play a role in the prevention or treatment of cerebral ischemia-hypoxic disease.