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本文研究冠状动脉造影前后血浆肾上腺髓质素（ＡＤＭ １３－ ５２）及内皮素（ＥＴ－ １）水平。用特异性放射免疫法测定冠状动脉正常人和冠状动脉病患者，冠脉造影前后血浆ＡＤＭ（１３－５２）及ＥＴ－１含量。结果表明冠脉造影后即刻血浆ＡＤＭ（１３－５２）和ＥＴ－１均明显升高，ＡＤＭ（１３－５２）从基础时３１．２３ ±１．１２ｐｇ／ｍＬ升高到４０．９１±１．２８ｐｇ／ｍＬ（Ｐ＜０．００１），ＥＴ－１从８８．８４±１０．５８ｐｇ／ｍＬ升高到１５８．２６ ± １３．６６ｐｇ／ｍＬ（Ｐ＜０．０１）。正常组及冠脉病组冠造术后血浆ＡＤＭ（１３－５２）及ＥＴ－１均较术前明显升高；但两组间比较，无论冠脉造影前后，ＡＤＭ或ＥＴ－１均无显著差异。ＡＤＭ（１３－５２）与ＥＴ－１的变化呈中等度的正相关（ｒ＝０．４４８４， Ｐ＜ ０． ００１）。因此，冠脉造影可使ＡＤＭ（１３－５２）及ＥＴ－１均升高，可能与造影剂对血管刺激、导管直接对血管内皮的刺激及交感神经兴奋性增高有关。ＥＴ—１可能作为一种中介因子，与冠脉造影的部分并发症有关，而与之作用相反的ＡＤＭ（１３－５２）升高可能是机体维持自身稳定的一种代偿性保护机制。
This article investigates the levels of plasma adrenomedullin (ADM 13-52) and endothelin (ET-1) before and after coronary angiography. The levels of plasma ADM (13-52) and ET-1 in patients with coronary artery disease and coronary artery disease before and after coronary angiography were measured by specific radioimmunoassay. The results showed that plasma ADM (13-52) and ET-1 were significantly increased immediately after coronary angiography, while ADM (13-52) increased from 31.23 ± 1.12pg / mL to 40.91 ± 1 at baseline. (P <0.001), ET-1 increased from 88.84 ± 10.58pg / mL to 158.26 ± 13.66pg / mL (P <0.01). The levels of plasma ADM (13-52) and ET-1 in patients with coronary artery disease and coronary artery disease after coronary angioplasty were significantly higher than those before surgery; however, ADM and ET-1 showed no significant difference between before and after coronary angiography difference. There was a moderate positive correlation between ADM (13-52) and ET-1 (r = 0.4484, P <0.001). Therefore, coronary angiography can make ADM (13-52) and ET-1 were elevated, may be related to the contrast medium and vascular stimulation, vascular endothelial stimulation and sympathetic nerve excitability increased. ET-1 may serve as a mediator, which is related to some complications of coronary angiography. In contrast, elevated ET-1 (13-52) may be a compensatory mechanism for the body to maintain its own stability.