阿尔茨海默病(alzheimer’s disease,AD)是最常见的老年期痴呆类型,属于皮质性痴呆.针对AD脑形态和结构的研究大多集中于脑灰质的改变,而对白质关注较少.近年来随着影像技术的发展,对AD脑白质改变的认识不断深入,本文将就早期AD的脑白质病变在弥散张量成像上的特点作以综述,对早期AD的脑白质改变在弥散峰度成像及磁共振波谱成像的特点进行简要说明.,Alzheimer’s disease (AD) is the most common type of dementia in the elderly .As AD is a type of cortical demen-tia, studies on the brain morphology of AD are mostly focused on the changes of gray matter and white matter is less conced .In recent years , with the development of imaging technology , research about the changes of white matter in AD develops quickly . This article provides a review of studies using diffusion tensor imaging methods to detect changes of white matter in brains of AD patients .The cerebral white matter on the early changes of AD are briefly introduced in the characteristics of diffusion kurtosis im -aging and magnetic resonance spectroscopy .