氟嗪酸(oflokacin)为新一代的喹酮酸类药物,本文对其正常人药代动力学进行了研究,并对血药浓度的微生物测定法及高效液相层析法测定结果进行了比较。健康志愿者8名接受氟嗪酸单次口服200、300和400mg后的体内过程相仿,血药峰浓度分别为2.47、4.37和5.85μg/ml。清除半衰期5h左右。在200～400mg给药剂量范 Oflokacin is a new generation of quinolones. In this paper, the normal human pharmacokinetics were studied, and the results of the determination of plasma concentration by microbiological assay and high performance liquid chromatography were compared . Eight healthy volunteers received oral inoculation with 200, 300 and 400 mg ofloxacin in a similar in vivo procedure with peak plasma concentrations of 2.47, 4.37 and 5.85 μg / ml, respectively. Clear half-life of about 5h. In the 200 ~ 400mg dose range