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巨噬细胞是体内执行免疫监视机能的重要效应细胞之一,可通过分泌和释放可溶性细胞毒因子对肿瘤细胞进行细胞外杀伤。本文报道维甲酸(RA)和维胺酸(R Ⅱ)可使小鼠腹腔巨噬细胞释放过氧化氢的能力增强。电镜观察表明,经药物激活的巨噬细胞对艾氏腹水癌细胞有明显的细胞外杀伤作用。预先给小鼠腹腔注射药物,然后腹腔接种10~4个艾氏腹水癌细胞,100%的动物不形成肿瘤。但增加瘤细胞接种数或改变给药途径,预防作用消失,这提示RA和R Ⅱ的抗肿瘤作用部分是通过激活的巨噬细胞完成的。
Macrophages are one of the important effector cells that perform immune surveillance functions in vivo. They can perform extracellular killing of tumor cells by secreting and releasing soluble cytotoxic factors. This article reports that retinoic acid (RA) and retinoic acid (R II) enhance the ability of mouse peritoneal macrophages to release hydrogen peroxide. Electron microscopy showed that drug-activated macrophages showed significant extracellular killing effect on Ehrlich ascites carcinoma cells. The mice were injected intraperitoneally with the drug in advance, and then 10 to 4 Ehrlich ascites cancer cells were inoculated intraperitoneally. 100% of the animals did not develop tumors. However, increasing the number of tumor cells inoculated or changing the route of administration, the prevention of the disappearance of the role, suggesting that the anti-tumor effect of RA and R II is partially accomplished by activated macrophages.