神经纤维瘤病以典型的皮肤损害及明确的家族史,而易于诊断。本文介绍1例以具有诊断意义的皮肤病变,由于周围神经分布区有多数肿块,CT 扫描提示为神经纤维瘤病。病例:50岁女性,大腿后下部有一肿块,伴以钝痛。皮肤未见泸泡斑,即使回顾检查中也仅见左腹股沟有一孤立的牛奶咖啡色斑股部及小腿后面有感觉运动障碍,并可扪及多数无搏动的肿块,因而行 CT 检查.CT 显示沿腰神经丛分支分布区,以及右侧坐骨神经、股神经、腓总神经、胫后神经分布区可见多数软组织肿块。肿块中央密度低,CT 值为16Hu,数个肿块周围有钙化。根据 CT 检查提出多发性神经纤维瘤病的诊断。切除侵及右侧坐骨神经及其分支的肿块,证实为良性神经纤维瘤。审查其家庭,病人 Neurofibromatosis is typically diagnosed with typical skin lesions and a clear family history. This article describes one patient with a diagnosis of skin lesions, due to a large number of tumors in the surrounding nerve distribution area, CT scan prompted neurofibromatosis. Case: A 50-year-old woman had a lump in the lower part of the thigh with dull pain. No plaques were found on the skin. Even in the retrospective examination, only the left inguinal region had an isolated milk coffee spot and a sensory dyskinesia behind the calf, and most of the non-beating lumps were visible. CT examination was performed along the CT. The distribution of the lumbar plexus branch, and the right sciatic nerve, femoral nerve, common peroneal nerve, posterior tibial nerve distribution visible most of the soft tissue mass. The central density of the mass was low, and the CT value was 16 Hu. There were calcifications around several lumps. The diagnosis of multiple neurofibromatosis was based on CT examination. The tumors that invaded the right sciatic nerve and its branches were resected and confirmed as benign neurofibromas. Examining their family, patient