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研究了组织胺H_2受体拮抗剂甲氰咪胍对垂体-性腺轴的影响。发现甲氰咪胍能显著减小LHRH刺激下LH、FSH和T反应曲线下绝对面积、降低峰值与基础值的比值和延缓峰值出现时间;而DHT分泌则无显著改变。研究结果表明组织胺H_2受体拮抗剂能抑制垂体LH和FSH的释放,由此使睾丸间质细胞T分泌减少。
The effect of histamine H 2 receptor antagonist cimetidine on the pituitary gonadal axis was investigated. It was found that cimetidine significantly reduced the absolute area under LHRH stimulation under the LH, FSH and T response curves, decreased the ratio of peak to basal value, and delayed the peak appearance time; while DHT secretion did not change significantly. The results show that histamine H 2 receptor antagonist can inhibit the release of pituitary LH and FSH, thereby reducing testicular stromal T cell secretion.