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自本世纪五十年代初鼠疟开始应用于抗药性研究以来,对鼠疟原虫抗药性培育的方法、抗性株的生物学特性以及抗性机理的探讨等,积累了丰富的实验资料。系统地分析这些资料对于了解人疟原虫产生抗药性的客观规律和进一步试图克服抗性具有一定实际意义。为此,本文就这一问题作一简要介绍。一、培育抗药性虫株的基本方法及其主要影响因素 (一)培育方法体内培育抗药性虫株的方法主要有两种,即逐代剂量递增法和大剂量复燃法。 1.逐代剂量递增法:将动物分为若干
Since malaria was first applied to drug resistance research in the early 1950s, a great deal of experimental data have been accumulated on the methods of resistance cultivation of P. falciparum, the biological characteristics of resistant strains and the mechanism of resistance. Systematic analysis of these data is of practical significance for understanding the objective law of resistance to Plasmodium falciparum and for further attempts to overcome resistance. To this end, this article gives a brief introduction to this issue. First, the basic method of cultivating resistant strains of insects and its main influencing factors (A) Cultivation methods There are two main ways to nurture drug-resistant strains in vivo, that is, the generation by dose escalating dose method and high-dose resurgence method. 1. Incremental dose by generation method: the animals divided into several