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利用CH_3 HEB/HeJ(脂多糖基因不敏感系,即LPS~-)和CH_3 HEB/FeJ(脂多糖基因敏感系,即LPS~+)小鼠,对热损伤后高甘油三酯血症机理进行了研究,以期阐明①热损伤是否可诱发LPS~-小鼠高甘油三酯血症;②LPS~+热损伤小鼠血清是否可诱发LPS~+非损伤小鼠高甘油三酯血症;③TNF-α抗体是否可抑制LPS~+热损伤小鼠的高甘油三酯血症;④LPS~+小鼠热损伤后其肝脏甘油三酯分泌率是否增加。小鼠造成15％TBSA烧伤,血浆甘油三酯含量按酶化法测定。实验分四步:①LPS~-和LPS~+小
Use of CH_3 HEB/HeJ (lipopolysaccharide gene-insensitive line, ie, LPS~-) and CH_3 HEB/FeJ (lipopolysaccharide gene-responsive line, or LPS~+) mice for the mechanism of hypertriglyceridemia following thermal injury Studies to clarify whether 1 thermal injury can induce hypertriglyceridemia in LPS~-mice;2 whether LPS~+ heat injured mice serum can induce hypertriglyceridemia in LPS~+ non-lesioned mice;3TNF- Whether α-antibody can inhibit hypertriglyceridemia in mice with LPS~+ heat injury; 4 Whether the hepatic triglyceride excretion rate in LPS~+ mice increases after heat injury. In mice, 15% of TBSA burns were caused and plasma triglyceride levels were measured by enzymatic method. The experiment is divided into four steps: 1LPS~- and LPS~+ small