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目的观察支气管哮喘患儿急性发作期血清白介素-4(IL-4)、白介素-10(IL-10)及干扰素-γ(IFN-γ)水平的变化,探讨支气管哮喘与血清IL-4、IL-10及IFN-γ的关系。方法收集2012年1月-2015年12月在该院收治的哮喘急性发作患者30例(哮喘急性发作组)、支气管肺炎患者30例(支气管肺炎组)及健康体检儿童30例(健康对照组),ELISA方法检测哮喘急性发作组治疗前后、支气管肺炎组及健康对照组患儿血清IL-4、IL-10及IFN-γ水平。结果哮喘急性发作组血清IL-4水平明显高于支气管肺炎组和健康对照组,血清IL-10及IFN-γ水平明显低于支气管肺炎组和健康对照组,差异均有统计学意义(P<0.01)。哮喘缓解期血清中IL-4水平较急性发作期明显下降(P<0.01),而IL-10及IFN-γ较急性发作期明显升高(P<0.01)。结论血清IL-4、IL-10及IFN-γ水平变化与哮喘发作密切相关,对监测哮喘患儿的病情发展有重要意义。
Objective To observe the changes of serum levels of interleukin-4, interleukin-10 and interferon-γ (IFN-γ) in children with bronchial asthma during acute exacerbation and to explore the relationship between bronchial asthma and serum IL-4, IL-10 and IFN-γ. Methods Thirty patients with acute exacerbation of asthma (acute exacerbation group), 30 patients with bronchopneumonia (bronchopneumonia group) and 30 healthy children (control group) were enrolled in this hospital from January 2012 to December 2015, Serum levels of IL-4, IL-10 and IFN-γ in children with bronchial pneumonia and healthy controls before and after treatment were measured by ELISA. Results Serum levels of IL-4 in patients with acute asthma were significantly higher than those in patients with bronchial pneumonia and healthy controls. Serum levels of IL-10 and IFN-γ were significantly lower than those in patients with bronchial pneumonia and healthy controls (P < 0.01). Serum levels of IL-4 in remission stage were significantly lower than those in acute stage (P <0.01), while levels of IL-10 and IFN-γ in serum were significantly higher than those in acute stage (P <0.01). Conclusion The changes of serum IL-4, IL-10 and IFN-γ levels are closely related to the onset of asthma, which is of great significance for monitoring the development of asthma in children.