上消化道出血的病人917例，分析其病因与ABO血型的关系，其中溃疡病487例，O型308例（63．2％），急性胃粘膜病变111例，O型57例（51．4％）。与两组正常人ABO血型分布比较，Ⅰ组为全国汉族人，O型占30．49％。Ⅱ组为贵州省中心血站资料，O型占33．65％。结果显示O型人患溃疡病及急性胃粘膜病变者较正常组明显增多，具有非常显著差异（P＜0．001），但胃癌组及肝病组与正常组比较无差异（P＞0．05）。O型血人易患溃疡病的原因与幽门螺杆菌易侵害O型抗原物质可能有关。 There were 917 cases of upper gastrointestinal bleeding, and their relationship with ABO blood group was analyzed. There were 487 cases of ulcer disease, 308 cases of type O (63.2%), 111 cases of acute gastric mucosal lesions, 57 cases of type O (51.4 %). Compared with the distribution of ABO blood group in normal controls, group Ⅰ was national Han nationality, O type accounted for 30.49%. Group Ⅱ center of Guizhou blood bank data, O-type accounted for 33.65%. The results showed that O-type patients with ulcer disease and acute gastric mucosal lesions than the normal group was significantly increased, with a significant difference (P <0.001), but gastric cancer group and liver disease group compared with the normal group was no significant difference (P> 0.05 ). O blood type susceptible to ulcer disease and Helicobacter pylori susceptible to O-antigen substances may be related.