以色列耶路撒冷Hadassah医院的一组研究人员研制了一种可以代替注射剂的口服胰岛素制剂。这种口服胰岛素的新方法正在进行早期临床试验。除目前主要使用的方法如一次性注射、皮下注射泵、鼻喷雾外,此药可能成为另一种治疗方法。注射技术可引起许多感染问题和不适,鼻喷雾可引起刺激,自动释放泵可以发生故障,在任何情况下,使用者只能在短期内获益。以色列研究组的设想是极力信仿胰岛素从胰腺流向肝脏的自然状况,使胰岛素从小肠吸收。研究人员必须解决两个问题:1.胰岛素分子太大(51个氮基酸链长),不能 A group of researchers at Hadassah Hospital in Jerusalem, Israel, has developed an oral insulin formulation that can replace injections. This new method of oral insulin is undergoing early clinical trials. In addition to the current main methods used such as disposable injection, subcutaneous injection pump, nasal spray, the drug may become another treatment. Injection techniques can cause a number of infection problems and discomfort, nasal spray can cause irritation, automatic release pump can malfunction, in any case, the user can only benefit in the short term. The Israeli team’s vision is to try hard to follow the natural state of insulin flowing from the pancreas to the liver, so that insulin is absorbed from the small intestine. Researchers must address two issues: 1. Insulin molecules are too large (51 amino acid chain length), can not