多巴胺拮抗剂能有效地治疗高催乳素血症。不过,对其长期疗效的估价尚不多。再者,某些副作用(恶心、直立性低血压、头痛)可能支持停用溴隐亭的想法。另一方面,在巨大摧乳素瘤的术后治疗中,撤消多巴胺拮抗剂常导致肿瘤再度扩展、临床症状复发,以及血浆催乳素(PRL)值增高。作者观察12名(男2、女10)、年龄32～69岁术后持续高PRL血症的病例,停用溴隐亭的影响。术后PRL值介于17与400ng/ml(平均73±107ng/ml;术前为166±245ng/ml),术后立即开始采用溴隐亭治疗,并连续18～59个月,剂量介于2.5与20mg/日之间。 采用溴隐亭治疗前及治疗期间的6例经CT扫描证实肿瘤再扩展;6例视野异常。全部病人中 Dopamine antagonists are effective in the treatment of hyperprolactinemia. However, the assessment of its long-term efficacy is still limited. Furthermore, some of the side effects (nausea, orthostatic hypotension, headaches) may support the idea of ​​stopping bromocriptine. On the other hand, withdrawal of dopamine antagonists often leads to re-expansion of the tumor, recurrence of clinical symptoms, and increased plasma prolactin (PRL) values ​​in postoperative treatment of macrophages. The authors observed 12 patients (male 2 and female 10) and aged 32 to 69 years with persistently high PRL hyperlipidemia. The effect of bromocriptine was discontinued. Postoperative PRL values ​​ranged from 17 to 400 ng/ml (mean 73±107 ng/ml; preoperatively 166±245 ng/ml). Immediately after surgery, bromocriptine was used for 18 to 59 months. Between 2.5 and 20 mg/day. Six cases before and during treatment with bromocriptine were confirmed by CT scan to reexpand the tumor; 6 cases had abnormal visual field. All patients