氟康唑(FLUCONAZOLE)是一种新型抗真菌药。最近美国食品药物管理局正式批准该药口服和静注用治疗隐球菌脑膜炎和各种念珠菌病。化学结构与作用机理:氟康唑是一种双一三唑,属于咪唑类抗真菌药,可抑制真菌细胞色素P—450依赖酶,阻断细胞膜上的重要物质—麦角甾醇的合成。活性:动物试验发现,该药在体内对多种全身性真菌病原体有抑制作用,包括曲 Fluconazole (FLUCONAZOLE) is a new antifungal agent. The United States Food and Drug Administration recently officially approved the drug oral and intravenous treatment of cryptococcal meningitis and a variety of candidiasis. Chemical structure and mechanism of action: Fluconazole is a bis-triazole, an imidazole antifungal agent, can inhibit the fungal cytochrome P-450-dependent enzyme, blocking the cell membrane of the important material - ergosterol synthesis. Activity: Animal tests found that the drug in vivo inhibition of a variety of systemic fungal pathogens, including the song