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以中药活性成分黄酮类化合物槲皮素与Zn(Ⅱ)的配合物为模板,以4-乙烯基吡啶为功能单体,乙二醇二甲基丙烯酸酯为交联剂,水溶性线性聚合物聚乙二醇(PEG,Mw=600)为添加剂,利用分子印迹技术紫外光引发原位聚合的方法制备了带支撑的锌离子配位分子印迹聚合物膜.使用扫描电镜测定了不同PEG用量下膜的表面形貌.通过膜渗透实验考察了PEG含量对金属配位印迹膜渗透速率的影响,系列印迹聚合物膜的识别体系及对不同底物的渗透选择性,同时考察了阳离子和阴离子对印迹膜渗透模板分子的影响.实验结果表明:制膜过程中水溶性线性聚合物PEG的加入可以明显改善膜的透过性能;槲皮素-Zn(Ⅱ)模板印迹聚合物膜对槲皮素表现出明显的渗透选择性,对槲皮素结构类似物芦丁和柚皮素的渗透选择性较差;且该金属配位印迹聚合物膜对不同阳离子和阴离子也都表现出较好的选择识别作用.
Using the complex of quercetin and Zn (Ⅱ), the active ingredient of Chinese traditional medicine, as the template, 4-vinyl pyridine as functional monomer and ethylene glycol dimethacrylate as the crosslinking agent, water-soluble linear polymer Polyethylene glycol (PEG, Mw = 600) was used as additive to fabricate a supported zinc ion coordination polymer molecularly imprinted polymer film by UV-induced in-situ polymerization using molecular imprinting technique.Using scanning electron microscopy The surface morphology of the membrane was investigated by means of membrane permeation experiments.The influence of PEG content on the permeation rate of the metal coordination membrane was investigated, the recognition system of the series of imprinted polymer membrane and the permeation selectivity to different substrates were investigated, and the cation and anion pairs Imprinted membrane infiltration template molecules.The experimental results show that: the film-forming process of water-soluble linear polymer PEG can significantly improve the membrane permeability; quercetin-Zn (Ⅱ) template imprinted polymer membrane on quercetin Showing obvious osmotic selectivity, less permeation selectivity to quercetin analogue rutin and naringenin, and the metal coordination polymer imprinted polymer film also shows good selectivity to different cations and anions Recognition.