为了估价中度运动可能刺激内皮细胞释放内皮素的作用,9例患者(糖尿病4、对照组5)行30分钟踏车试验。工作负荷达预计最高值的40%。在运动前、后即刻测定 ADP(1.25,2.5、5μmol)诱导的血小板聚集反应和下列血浆参数:去甲肾上腺素(NEnmol/l)、11去氢 TxB2(pg/ml)、GH(ng/ml)、内皮素(ET-1、ET-2、大 ET-1,fmol/ml)。在运动前,对照组(中位数8)和糖尿病(中位数13)血浆内皮素浓度差异无显著意义。作为总体看,9例运动后下列指标 In order to assess the role of moderate exercise may stimulate endothelium release of endothelin, nine patients (diabetes 4, control group 5) for 30 minutes treadmill test. Workload up to 40% of projected maximum. ADP (1.25, 2.5, 5 μιηοΐ) induced platelet aggregation and the following plasma parameters were measured before and after exercise: norepinephrine (NEnmol / l), hydrogen deconjugation TxB2 (pg / ml), GH ), Endothelin (ET-1, ET-2, large ET-1, fmol / ml). Before exercise, there was no significant difference in plasma endothelin concentrations between the control group (median 8) and diabetes (median 13). As a whole, the following indicators of 9 cases after exercise