Q热的病原体贝氏柯克斯体是专性细胞内寄生菌,该菌的高致病性和对环境、理化因素的高抵抗力使其成为重要的生物战剂/生物恐怖剂。进入宿主细胞后,Cb能在巨噬细胞内生长繁殖,导致单核细胞朝向非典型M2分化;它通过抑制树突细胞的成熟,干扰细胞因子的正常分泌等多种方式调控宿主细胞的免疫机制,从而逃避机体对其的免疫攻击。 Q hot pathogens C. cynoglossus is an obligate intracellular parasite that has become an important biological warfare / bioterrorism agent due to its high pathogenicity and high resistance to environmental, physical and chemical factors. After entering the host cells, Cb can grow and multiply in macrophages, leading to mononuclear cells toward atypical M2 differentiation; it can regulate the immune mechanism of host cells by inhibiting the maturation of dendritic cells and interfering with the normal secretion of cytokines , Thus avoiding the body’s immune attack.