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目的 对脑缺血再灌注损伤大鼠应用旋磁场后 ,观察超氧化物歧化酶 (SOD)、丙二醛(MDA)、前列环素 (PGI2 )、血栓素 (TXA2 )及血液流变学指标的变化。方法 实验动物分 3组 ,每组12只。对照组做假手术 ;再灌组 ,旋磁组双侧颈总动脉夹闭 30min ,再灌注 30min(旋磁组大鼠夹闭颈总动脉后置于旋磁场内 ,鼠体中心部分距磁极为 6cm ,磁感应强度为 30mT) ,腹主动脉取血进行观察。结果 旋磁组SOD活力和PGI2 水平分别为 ( 172 .5 3± 9.15 )NU/ml,( 80 1.88±12 2 .70 ) pg/ml,显著高于再灌组 ( 16 2 .34± 7.5 0 )NU/ml,( 5 48.0 8± 12 8.15 ) pg/ml(P <0 .0 5 ,<0 .0 1) ;MDA含量和TXA2 水平为 ( 7.74± 0 .94)nmol/ml,( 40 5 .2 3± 79.5 2 )pg/ml,显著低于再灌组 ( 9.19±1.43)nmol/ml,( 5 11.45± 10 2 .2 7) pg/ml(P <0 .0 5 ) ;同时 ,旋磁场可降低红细胞压积 ,使红细胞解聚 ,增加其变形能力。结论 旋磁场可通过降低自由基 ,调节TXA2 /PGI2 比值 ,降低血液粘稠度 ,改善血液循环状态 ,对脑缺血再灌注损伤有一定保护作用
Objective To observe the effects of cyclosporin on cerebral ischemia-reperfusion injury in rats, and observe the changes of superoxide dismutase (SOD), malondialdehyde (MDA), prostacyclin (PGI2), thromboxane (TXA2) The change. Methods Experimental animals were divided into 3 groups, 12 in each group. In the reperfusion group, bilateral common carotid arteries were clamped for 30 minutes and reperfused for 30 minutes in the reperfusion group (the carotid group was placed in a rotating magnetic field after clamping the common carotid artery, the center part of the body was 6cm, magnetic induction intensity of 30mT), abdominal aorta blood was observed. Results The levels of SOD and PGI2 in spinosad were (172.53 ± 9.15) NU / ml and (80 1.88 ± 12 2 .70) pg / ml, respectively, which were significantly higher than those in reperfusion group (16.234 ± 7.5 0 (P <0.05, <0.01); the levels of MDA and TXA2 were (7.74 ± 0.94) nmol / ml, (40.0 8 ± 12 8.15) pg / 5. 23 ± 79.5 2) pg / ml was significantly lower than that of the reperfusion group (9.19 ± 1.43 nmol / ml, (5 11.45 ± 10 2 .27) pg / ml , Rotating magnetic field can reduce hematocrit, red blood cell depolymerization, increase its ability to deform. Conclusion Rotating magnetic field can reduce the free radical, regulate TXA2 / PGI2 ratio, reduce blood viscosity, improve blood circulation, and have a protective effect on cerebral ischemia-reperfusion injury