将小鼠骨皮质移植在同系小鼠的腹部皮下，２周后取出进行体外培养。结果表明：骨皮质内的基质细胞具有很强的增殖能力，经过４～５周纯化后，体系内可见大量的基质细胞和细胞球；与骨髓细胞进行比较，发现此细胞较骨髓内基质细胞贴壁时间稍晚，但细胞增殖力较强，贴壁层内细胞组成及特性与骨髓基质细胞相似。提示骨皮质或骨小梁是骨髓基质细胞的源泉，其内的细胞在特定条件下，可以分化成造血基质细胞 The mouse cortical bone was transplanted subcutaneously in the abdomen of homologous mice and removed after 2 weeks for in vitro culture. The results showed that the stromal cells in cortical bone had strong proliferative ability. After 4 to 5 weeks of purification, a large amount of stromal cells and spheres were seen in the system. Compared with bone marrow cells, Wall time later, but stronger cell proliferation, adherent layer cell composition and characteristics similar to bone marrow stromal cells. Tip cortical or trabecular bone marrow stromal cells is the source of its cells under specific conditions, can differentiate into hematopoietic stromal cells