目的:观察含草酸铂和羟基喜树碱的联合化疗方案治疗晚期胃癌的近期疗效及不良反应。方法:化疗方案(OHLF3方案):草酸铂130mg/m2,静滴,第1日;羟基喜树碱6mg/m2,静滴,第1~5日;甲酰四氢叶酸钙200mg/m2,静滴2小时,第1~3日;5-氟脲嘧啶400mg/m2,快速静注,追加600mg/m2,持续静滴22小时,第1~3日,每21日为一周期,完成3周期后判定疗效,有效病例4周后确认。结果:全组39例患者,实际可评价疗效患者36例,总有效率(CR+PR)为50%(18/36);主要不良反应为轻度的血液学毒性、恶心呕吐和外周感觉神经异常。结论:含草酸铂和羟基喜树碱的OHLF3方案是治疗晚期胃癌有效且毒性较小的联合化疗方案。 OBJECTIVE: To observe the short-term curative effect and adverse reactions of combined chemotherapy regimen containing oxaliplatin and hydroxycamptothecin in the treatment of advanced gastric cancer. Methods: The chemotherapy regimen (OHLF3 regimen): oxaliplatin 130mg / m2, intravenous infusion, on the 1st; hydroxycamptothecin 6mg / m2, intravenous infusion, 1st to 5th; leucovorin 200mg / m2, Drip 2 hours, the first to 3 days; 5-fluorouracil 400mg / m2, rapid intravenous injection, additional 600mg / m2, intravenous infusion of 22 hours, 1 to 3 days, every 21 days for a cycle to complete 3 cycles After determining the efficacy of effective cases confirmed after 4 weeks. Results: In the 39 patients in the whole group, there were 36 patients with clinically evaluable efficacy and the total effective rate (CR + PR) was 50% (18/36). The main adverse reactions were mild hematological toxicity, nausea and vomiting, and peripheral sensory nerve abnormal. CONCLUSION: The OHLF3 regimen containing oxaliplatin and hydroxycamptothecin is a potent and less toxic combination regimen for advanced gastric cancer.