目的：探讨内皮素在急性肝衰竭时肾功能障碍发生中的作用。方法：对硫代乙酰胺（ＴＡＡ）诱导的急性肝衰竭大鼠肝肾功能及内皮素水平进行动态观察。结果：随着肝损伤的加重，肾功能亦进行性恶化（表现为血肌酐升高，肌酐清除率下降，尿量减少，尿钠分泌降低等），血浆内毒素逐渐升高，均于４８ｈ最为严重。伴随上述变化，肾组织内皮素活性渐升高，亦于４８ｈ达高峰。血浆内皮素和肌酐清除率及肌酐清除率与肾组织内皮素水平之间均呈显著负相关，而血浆内皮素水平却无显著变化。结论：内皮素在急性肝衰竭时肾功能障碍的发生中起重要作用，但它与内毒素之间似乎具有某种关系 Objective: To investigate the role of endothelin in the pathogenesis of renal dysfunction in acute liver failure. Methods: The dynamic changes of liver and kidney function and endothelin level in rats with acute hepatic failure induced by thioacetamide (TAA) were observed. Results: With the aggravation of liver injury, renal function was also deteriorated (manifested by increased serum creatinine, decreased creatinine clearance, decreased urine output, decreased urinary sodium secretion, etc.), plasma endotoxin gradually increased, the most in 48h serious. With the above changes, endothelin activity in renal tissue gradually increased, reaching a peak at 48h. Plasma endothelin and creatinine clearance and creatinine clearance and renal tissue endothelin levels were significantly negative correlation, while plasma endothelin levels did not change significantly. CONCLUSION: Endothelin plays an important role in the development of renal dysfunction in acute liver failure, but it appears to have some relationship with endotoxin