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通气不足会引起肺血管收缩、减少血流量以协调通气／血流比值，从而有助于动脉血氧分压的维持。本实验的目的是了解机体是否存在反向调节，肺血流减少能否引起气道收缩。在离体灌注大鼠肺实验，肺循环灌注量减少７０～９０％，１ｍｉｎ时肺阻力有所下降。在整体家兔实验，用气囊阻断下腔静脉血流使肺循环灌注量减少１２～３０％，肺阻力由６．６５±１．４９下同）降至６．４８±１．６１（３ｍｉｎ时）和６．４０±１．７４（５ｍｉｎ时）Ｐａ·ｓ／ｍｌ，Ｐ＜０．０５，配对ｔ检验。由此可见，肺血流量的减少不能通过收缩气道而引起通气量减少，机体在维持肺通气／血流比值的机制中可能不存在双向调节。
Inadequate ventilation can cause pulmonary vasoconstriction, reducing blood flow to coordinate ventilation / blood flow ratio, which contribute to the maintenance of partial pressure of arterial oxygen. The purpose of this experiment is to understand whether there is reverse regulation of the body, pulmonary blood flow can reduce airway contraction caused. In vitro perfusion rat lung experiments, pulmonary perfusion decreased by 70 to 90%, 1min lung resistance decreased. In the whole rabbit experiment, the use of balloon occlusion of inferior vena cava blood flow to reduce pulmonary perfusion volume 12 to 30%, lung resistance from 6.65 ± 1.49 the same below) to 6.48 ± 1.61 (3min ) And 6.40 ± 1.74 (5 min) Pa · s / ml, P <0.05, paired t test. Thus, the reduction of pulmonary blood flow can not be caused by the contraction of the airway to reduce the ventilation, the body in maintaining lung ventilation / blood flow ratio mechanism may not exist two-way adjustment.