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采用基于混合线性模型的关联分析方法,检测了身体质量指数(BMI)的相关基因及其相互作用,分析了吸烟和性别对身体质量指数的影响.研究的基因型和表型数据取自慢性阻塞性肺病研究数据库.结果检测到与身体质量指数有关的20个基因以及2对上位性基因,并发现了受吸烟影响及与性别有关的特定基因及其作用方式.检测到与吸烟无关的9个基因,对BMI有较大影响(遗传率为31.23%),并且影响肥胖、糖尿病等7种疾病.吸烟导致的5个基因都能增加BMI,但并不导致肥胖、糖尿病等疾病.生物信息学分析揭示了与身体质量指数相关的基因存在复杂的遗传网络.研究结果表明,吸烟等生活行为的个性化检测对肥胖等复杂疾病的预防及治疗至关重要.
The correlation analysis of body mass index (BMI) and its interaction was performed using a correlation analysis based on a mixed linear model, and the effects of smoking and sex on body mass index were analyzed.The genotype and phenotype data were from chronic obstruction Lung disease research database.Results Twenty genes related to body mass index and two pairs of epistatic genes were detected and found to be influenced by smoking and gender-specific genes and their mode of action.A total of 9 Gene has a great impact on BMI (heritability of 31.23%), and affects 7 kinds of diseases such as obesity and diabetes, etc. All 5 genes caused by smoking can increase BMI, but not lead to diseases such as obesity and diabetes. The analysis revealed a complex genetic network of genes associated with the body mass index.The results show that individualized testing of life behaviors such as smoking is crucial for the prevention and treatment of complex diseases such as obesity.