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美《柳叶刀》杂志第2卷第8141期(1979年9月8日)第510页报道:积极寻找更有效的紧急抗高血压疗法的热情,可能被牛津最近发表的文章而缓和下来。Ledingham和Rajago-Palon描述了10名恶性高血压患者,多数在静脉注射重氮氧化物后,随着血压的迅速下降,出现了急性神经症状。3名患者神经症状未消除而死亡。尸检表明,随着血压的下降可能发生了急性脑缺血性损伤。这些令人困惑的报告已不是首次,提示临床医生对高血压进行紧急治疗之前,应考虑到他的治疗在病人身上可能引起的各种生理反应。大量的证据说明,高血压是发生中风的主要危险因素;同样有力的证据说明,控制血压能降低中风的发病率。甚至对曾患中风并已恢复
Volume 2, Issue 8141 (September 8, 1979) page 510 of The Lancet: Enthusiasm to actively seek more effective emergency antihypertensive treatment may be moderated by the recent Oxford paper. Ledingham and Rajago-Palon described 10 patients with malignant hypertension, most of which developed acute neurological symptoms as their blood pressure dropped rapidly after intravenous diazoxide. Three patients died of neurological symptoms without elimination. Autopsy shows that with the decline in blood pressure may occur acute cerebral ischemic injury. These puzzling reports are not the first to prompt clinicians to consider the various physiological reactions that his treatment may cause in patients before emergency treatment of hypertension. There is ample evidence that hypertension is a major risk factor for stroke; equally compelling evidence suggests that controlling blood pressure can reduce the incidence of stroke. He had even suffered a stroke and has recovered