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目的探讨二尖瓣环钙化(MAC)与冠心病之间关系,明确MAC能否作为冠心病的独立预测因子。方法对128例年龄≤65岁MAC患者和86例对照者进行冠状动脉造影和超声心动图检查。结果①与对照组比较,MAC组冠状动脉造影阳性率显著增高(88.28%对65.12%,P=0.000),且更容易发生左冠状动脉主干狭窄(15.63%对4.65%,P=0.013)和三支冠状动脉狭窄(55.47%对32.56%,P=0.001);②MAC是冠心病的独立预测因子(P=0.008),其预测价值高于冠心病传统的预测因子高脂血症(P=0.02)、胸痛(P=0.03)和年龄(P=0.04);③MAC对冠心病的阳性预测值为88.28%。结论MAC与冠心病之间存在十分密切的关系,能够作为冠状动脉造影检查的术前筛选指标,提高冠状动脉造影检查的阳性率。
Objective To investigate the relationship between mitral annular calcification (MAC) and coronary heart disease (CHD) and to determine whether MAC can be used as an independent predictor of coronary heart disease. Methods 128 cases of MAC patients aged ≤ 65 years and 86 controls were examined by coronary angiography and echocardiography. Results ① Compared with the control group, the positive rate of coronary angiography in MAC group was significantly higher (88.28% vs 65.12%, P = 0.000), and was more likely to occur in the left main coronary artery stenosis (15.63% vs 4.65%, P = 0.013) (55.47% vs 32.56%, P = 0.001); ②MAC was an independent predictor of coronary heart disease (P = 0.008) and its predictive value was higher than the traditional predictor of hyperlipidemia (P = 0.02) , Chest pain (P = 0.03) and age (P = 0.04). ③ The positive predictive value of MAC for coronary heart disease was 88.28%. Conclusion There is a close relationship between MAC and coronary heart disease, which can be used as a preoperative screening index for coronary angiography and to improve the positive rate of coronary angiography.