血友病为一种X染色体伴隐性遗传的出血性疾病.血友病伴唇裂畸形病例更为少见.我院共收治3例血友病唇裂患儿,采用术前、术中、术后48小时内纠正凝血因子缺乏,使凝血因子Ⅷ、Ⅸ在血浆中的浓度术前分别保持在75%、50%以上,48小时后保持在30%、32%以上,手术年龄1岁左右,采用三角瓣法整复,术中注意减少创伤,缝合严密.3例经手术整复成功,无术后出血及复裂. Hemophilia is a hereditary hemorrhagic disease with X chromosome hemophilia associated with cleft lip deformity cases were treated in our hospital were treated 3 cases of children with hemophilia cleft lip, using preoperative, intraoperative and postoperative 48 hours to rectify the lack of clotting factor so that the blood coagulation factor Ⅷ, Ⅸ in plasma concentrations were maintained at 75%, 50%, 48 hours later maintained at 30%, 32%, the operative age of 1 year old, using Triangular flap method, the surgery to reduce trauma, suture tight .3 cases of successful surgery, no postoperative bleeding and rupture.