幽门螺杆菌感染与胃癌患病概率增加之间的关联引发了人们关于结肠微生物群与结直肠癌之间可能有关联的想法。输卵管灌气法导致的结肠上皮细胞被产肠毒素脆弱拟杆菌侵袭可能会增加癌变前细胞分化的风险。然而,幽门螺杆菌、脆弱拟杆菌等可调整正常宿主对感染的应答。因此,Keenan等推测,产肠毒素脆弱拟杆菌的侵袭可能是结肠癌发生因素中未被重视 The link between Helicobacter pylori infection and the increased probability of gastric cancer raises the idea that there may be a link between colon microflora and colorectal cancer. Tubal infiltration caused by colonization of colon epithelial cells with enterotoxigenic Bacteroides fragilis may increase the risk of pre-cancerous cell differentiation. However, Helicobacter pylori, Bacteroides fragilis, etc. can regulate the response of normal hosts to infection. Therefore, Keenan et al. Hypothesize that the invasion of Bacteroides fragilis-producing Bacteroides may not be valued in the pathogenesis of colon cancer