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本文综合第一次国际白血病染色体协作会议有关慢性粒细胞性白血病(CGL)的材料,旨在了解 Ph＇阳性的CGL不同时期核型异常的发生率,并探讨应用细胞遗传学作为病情预测的可能性。符合统一标准(完整的临床资料和作带型分析的细胞核型)的病人共223例(男111,女112),分成4组进行比较,结果见528页表。8％病例有少见的复杂的易位。18种易位中,8种累及22号及一个其他染色体,9种累及9号、22号及一个以上其他染色体,1例没有测出22号染色体的
This article synthesizes the first International Leukemia Chromosome Collaborative Materials on Chronic Myelogenous Leukemia (CGL) to understand the incidence of karyotypic abnormalities in Ph ’-positive CGL at different stages and to explore the possibility of using cytogenetics as a prognosis for disease Sex. A total of 223 patients (male 111, female 112) who met the uniform criteria (complete clinical data and karyotypes for banding analysis) were divided into 4 groups for comparison, and the results are shown on the 528-page table. 8% of cases have rare and complex translocations. Of the 18 translocations, 8 involved 22 and one other chromosome, 9 involved 9, 22, and more than one other chromosome, and 1 did not detect chromosome 22