千金藤素(cepharanthin)已在临床上广泛应用。早已证明它行免疫激活、增强脾细胞NK活性及肺Mφ活性和抗肿瘤等作用。作为生物反应调节剂可能对与器官相关的天然免疫有调节作用。为阐明其在上述领域中的作用机理,本文用器官相关的NK细胞研究了千金藤素的影响。肿瘤细胞用A/Sn小鼠YAC-1淋巴瘤及Ehrlich癌JTC-11细胞。效应细胞用脾、淋巴结、肺、肝的NK细胞及肺和肝的Mφ细胞。 Cepharanthin has been widely used in clinical practice. It has long been demonstrated that it activates immune activity, enhances splenocyte NK activity, lung Mφ activity, and anti-tumor effects. As a biological response modifier, it may have a regulatory effect on organ-associated innate immunity. In order to elucidate its mechanism of action in the above-mentioned fields, the effects of panacin were studied using organ-associated NK cells. Tumor cells used A/Sn mouse YAC-1 lymphoma and Ehrlich cancer JTC-11 cells. Effector cells use spleen, lymph node, lung, liver NK cells and lung and liver Mφ cells.