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脂肪细胞分化过程中，细胞内脂肪细胞型脂肪酸结合蛋白、葡萄糖转运蛋白4及过氧化物酶体增殖物激活受体γ等蛋白异常表达，可能与糖及脂肪代谢、肥胖症、2型糖尿病、脂肪肝、高脂血症和乳腺癌等重大生命和疾病过程有非常密切的关系，使得脂肪细胞的分化过程成为近年来研究的热点之一。而微 RNA（miRNA）是一种小分子的内生的非编码 RNA，可选择性地催化信使 RNA 裂解，调节基因的表达。“,”In adipocyte differentiation ,the abnormal expression of intracellular adipocyte fatty acid bind-ing protein,glucose transporter 4 and peroxisome proliferator activated receptor γmay have very close rela-tionship with major life and disease processes including sugar and fat metabolism,obesity,type 2 diabetes, fatty liver,hyperlipidemia and breast cancer,therefore the adipocyte differentiation process has become one of the hot spots in recent years.And microRNA(miRNA) is a small molecule endogenous non-encoding RNA, which can selectively catalyze the cleavage of messenger RNA and regulate gene expression .