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在30只猫阻断一支冠脉造成急性心肌缺血后,观察刺激迷走神经对心电图(ECG)、心率、血压以及心率收缩压乘积的影响。结果表明,暂时阻断冠脉前降支或左旋支后,ECG的ST段急剧上升,T波振幅增大。收缩压明显降低,但舒张压和心率无明显变化。刺激迷走神经时,ECG的ST段变化明显减轻,甚至恢复正常。在主动脉和右心房间的沟内将甲醛注入心房肌内,使心率减慢后,再阻断冠脉,ECG变化仍出现。左心室内注入50μg乙酰胆硷(Ach),阻断冠脉后,ECG变化消失。静脉滴注甲氧胺C(1mg/min)共5mg,阻断冠脉时的ECG变化明显减轻,与刺激迷走神经时相似。心率收缩压乘积与ST段和T波振幅变化无直接关系。这些结果提示,刺激猫的颈迷走神经确可改善或消除冠脉阻断后ECG的变化,且并非由于刺激迷走神经造成的心率减慢所致,而主要是由于迷走神经的直接作用。
After 30 cats blocked a coronary artery causing acute myocardial ischemia, the effect of stimulating the vagus nerve on the product of electrocardiogram (ECG), heart rate, blood pressure, and heart rate systolic pressure was observed. The results showed that, after temporarily blocking the anterior descending coronary artery or left circumflex coronary artery, the ST segment of ECG increased sharply and the amplitude of T wave increased. Systolic blood pressure decreased significantly, but no significant changes in diastolic blood pressure and heart rate. Stimulation of the vagus nerve, ECG ST segment changes significantly reduced, or even returned to normal. In the aorta and right atrium of the groove will be injected formaldehyde into the atrial muscle, the heart rate slowed down, and then cut off the coronary artery, ECG changes still occur. Left ventricular injection of 50μg acetylcholine (Ach), after the coronary artery is blocked, ECG changes disappear. Intravenous infusion of methoxyamine C (1mg / min) a total of 5mg, ECG changes in coronary artery obstruction significantly reduced, similar to the vagus nerve stimulation. Heart rate systolic pressure product and ST segment and T wave amplitude is not directly related. These results suggest that stimulating neck vagus nerve in cats may improve or eliminate ECG changes after coronary occlusion, and not because of the slow heart rate caused by vagus nerve stimulation, but mainly because of the direct effect of vagus nerve.