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为查明乙型肝炎病毒(HBV)感染后是否增加人免疫缺陷病毒Ⅰ型(HIV-1)的易感性,作者进行了此项研究分析。研究对象为美国4个城市(巴尔的摩、芝加哥、洛杉矶和匹兹堡)的艾滋病研究中心在1984年4月至1985年4月登记的4498名非艾滋病男性同性恋者。按照统一调查表,了解受试者的既往史、吸毒史、乙型肝炎(HB)疫苗接种史、性行为和性病史。对所有受试者从开始研究起的2年半内,每半年采血一次,用酶联免疫试验检测血清HIV-1抗体,用放射免疫法检测HBsAg及抗-
To determine if Hepatitis B virus (HBV) increases susceptibility to human immunodeficiency virus type 1 (HIV-1), the authors conducted this study. The study looked at 4498 non-AIDS gay men registered in April 1984-April 1985 in four U.S. cities (Baltimore, Chicago, Los Angeles and Pittsburgh). Follow the Unified Questionnaire to find out the subject’s past history, drug abuse history, hepatitis B (HB) vaccination history, and sexual and venereal history. All subjects took blood samples once every six months from the first study in two and a half years. Serum HIV-1 antibody was detected by enzyme-linked immunosorbent assay (ELISA), HBsAg and anti-