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目的： 研究幽门螺杆菌（Ｈｐ） 根除对长期服用非甾体消炎药（ＮＳＡＩＤ） 的消化性溃疡愈合和复发的影响。方法：将６９ 例长期服用ＮＳＡＩＤ的消化性溃疡患者分为Ｈｐ 阳性雷尼替丁组２５ 例，Ｈｐ 阳性雷尼替丁加阿莫西林组２３ 例， Ｈｐ 阴性雷尼替丁组２１例， 三组的用药时间均为６周。结果： 三组溃疡愈合率依次为６４％ 、７４％ 、７１％（Ｐ＞ ０．０５）。追踪溃疡愈合者４３ 例， 并分为Ｈｐ 根除组１３ 例， Ｈｐ 持续阳性组１６ 例， Ｈｐ 持续阴性组１４ 例。均停用抗溃疡药物， 继续服用ＮＳＡＩＤ６ 个月后复查。累计溃疡复发率三组分别为３１％ 、４４％ 、２９％ （Ｐ＞ ０．０５）。结论： 根除Ｈｐ 不能提高ＮＳＡＩＤ相关消化性溃疡的愈合率， 亦不能降低其复发率， 且Ｈｐ 持续阳性者其溃疡复发率有升高趋势
Objective: To study the effect of Helicobacter pylori (Hp) eradication on peptic ulcer healing and relapse after long-term administration of non-steroidal anti-inflammatory drugs (NSAIDs). Methods: A total of 69 patients with peptic ulcer who took NSAID for long time were divided into 25 cases of Hp positive ranitidine group, 23 cases of Hp positive ranitidine plus amoxicillin group, 21 cases of Hp negative ranitidine group, Group medication time are 6 weeks. Results: The healing rates of the three groups were 64%, 74% and 71%, respectively (P> 0.05). 43 cases were followed up for ulcer healing, and were divided into Hp eradication group (13 cases), Hp persistent positive group (16 cases) and Hp persistent negative group (14 cases). All anti-ulcer drugs were discontinued, and NSAIDs continued to be examined after 6 months. The cumulative ulcer recurrence rates in the three groups were 31%, 44% and 29%, respectively (P> 0.05). Conclusion: The eradication of Hp can not improve the healing rate of NSAID-associated peptic ulcer, and can not reduce the recurrence rate, and the recurrence rate of ulcer in Hp persistently increases