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目的:探讨桂枝茯苓胶囊与抗菌药物联用对慢性盆腔炎患者的临床疗效及其对超敏C反应蛋白(hsCRP)、白介素-2(IL-2)水平的影响。方法:选取2012年6月—2016年2月间收治的慢性盆腔炎且中医证型属于气滞血淤的99例患者,将其分为对照组49例和观察组50例;对照组患者给予依据《慢性盆腔炎治疗用药指南》要求,采用头孢曲松钠及替硝唑静脉滴注抗感染治疗,观察组患者在对照组基础上加用桂枝茯苓胶囊口服治疗;比较两组患者治疗前后血浆黏度、血黏度(低切、高切)等血液流变学指标,以及肿瘤坏死因子(TNF-α)、IL-2、hs-CRP等炎症指标及按症状的评分值变化情况、临床疗效及复发率的差异。结果:治疗后,观察组患者下腹痛、腰骶痛、月经量等症状的评分值低于对照组(P<0.05),总有效率高于对照组(P<0.05);观察组患者血浆黏度、血黏度、TNF-α、CRP水平均低于对照组,而IL-2值高于对照组(P<0.05)。结论:采用桂枝茯苓胶囊与抗菌药物联用治疗气滞血淤型慢性盆腔炎患者的疗效较为显著,可有效改善血液流变学及炎症各指标,优于单用抗菌药物治疗。
Objective: To investigate the clinical effect of Guizhi Fuling Capsule combined with antibacterials on chronic pelvic inflammatory disease and its effect on the levels of hsCRP and IL-2. Methods: Ninety-nine patients with chronic pelvic inflammatory disease who were admitted to our hospital from June 2012 to February 2016 and whose syndromes of qi stagnation were blood stagnation were divided into control group (49 cases) and observation group (50 cases). Patients in the control group According to “chronic pelvic inflammatory disease treatment guideline” requirements, the use of ceftriaxone sodium and tinidazole intravenous infusion of anti-infective treatment, the observation group patients in the control group based on the use of Guizhi Fuling capsule oral treatment; compared two groups of patients before and after treatment The indexes of hemorheology such as plasma viscosity, blood viscosity (low-cut, high-cut) and the indexes of inflammation such as tumor necrosis factor (TNF), IL-2 and hs-CRP, And the difference of recurrence rate. Results: After treatment, the scores of lower abdominal pain, lumbosacral pain and menstrual flow in the observation group were lower than those in the control group (P <0.05), and the total effective rate was higher than that in the control group (P <0.05). The plasma viscosity , Blood viscosity, TNF-α, CRP levels were lower than the control group, while the IL-2 value was higher than the control group (P <0.05). Conclusion: Guizhifuling capsule combined with antibacterial drugs in the treatment of patients with chronic pelvic inflammatory disease of qi stagnation and blood stagnation is more effective, which can effectively improve the indexes of hemorheology and inflammation, which is better than that of antibiotics alone.