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目的评价广东省现行高效抗逆转录病毒治疗(HAART)方法对治疗艾滋病病毒感染者/患者(HIV/AIDS)的免疫疗效和病毒抑制疗效。方法通过中国疾病预防控制信息系统中的艾滋病综合防治信息系统收集广东省HIV/AIDS病例的HAART治疗数据信息,采用免疫学指标CD4+T淋巴细胞计数和病毒学指标HIV病毒载量(VL)进行评价。结果 2004—2013年共有12 886例HIV/AIDS病例接受了HAART治疗,其中男性9 393例,女性3 493例,平均年龄(40.94±11.87)岁,平均接受抗病毒治疗时间(28.17±24.28)个月。基线时CD4+T淋巴细胞计数<200个/μL的患者占61.63%(7 941/12 886),200~350个/μL的占33.08%(4 263/12 886),>350个/μL的占5.29%(682/12 886)。治疗后最后1次CD4+T淋巴细胞计数<200个/μL的占21.32%(2 747/12 886),200~350个/μL的占31.17%(4 017/12 886),>350个/μL的占47.51%(6 122/12 886)。同基线时相比,不同治疗时间病例的CD4+T淋巴细胞计数均明显升高,差异均有统计学意义(均P<0.01)。12 886例病例接受HAART后,1 833例(占14.22%)VL≥400 CP/m L,病毒抑制失败;11 053例VL<400 CP/m L,病毒抑制率为85.78%。接受HAART治疗3个月、6个月、1年、2年、3年时,病毒抑制率分别为14.42%、84.25%、91.01%、90.56%、90.86%。结论广东省HIV/AIDS对HAART有较好的病毒学及免疫学应答,现行的艾滋病HAART治疗疗效较好,应进一步提高抗病毒治疗覆盖率。
Objective To evaluate the immunotherapy efficacy and virus suppression efficacy of the current highly active antiretroviral therapy (HAART) in Guangdong Province for the treatment of HIV / AIDS. Methods The data of HAART treatment in HIV / AIDS cases in Guangdong Province were collected through the AIDS Integrated Prevention and Control Information System of China CDC. The immunological indexes CD4 + T lymphocyte count and virological indicator of HIV viral load (VL) Evaluation. Results A total of 12 886 HIV / AIDS cases were enrolled in HAART from 2004 to 2013. There were 9 393 males and 3 493 females with an average age of (40.94 ± 11.87) years and an average duration of antiviral therapy (28.17 ± 24.28) month. 61.63% (7941/12886) of patients with CD4 + T lymphocyte count <200 cells / μL at baseline, 33.08% (4 263/12886) with 200-350 cells / μL and> 350 cells / μL Accounting for 5.29% (682/12 886). 21.32% (2 747/12 886) of the last 1 CD4 + T lymphocyte count <200 / μL, 31.17% (4 017/12 886) of 200-350 / μL,> 350 / μL accounted for 47.51% (6 122/12 886). Compared with the baseline, CD4 + T lymphocyte counts were significantly increased in different treatment time cases, the differences were statistically significant (P <0.01). After 12 886 cases received HAART, 1833 cases (14.22%) had VL≥400 CP / m L, and the virus failed to fail. 11 053 cases had VL <400 CP / m L and the virus inhibition rate was 85.78%. After 3 months, 6 months, 1 year, 2 years and 3 years of HAART treatment, the virus inhibition rates were 14.42%, 84.25%, 91.01%, 90.56% and 90.86% respectively. Conclusion HIV / AIDS in Guangdong Province has a good virological and immunological response to HAART. The current HIV / AIDS HAART therapy is effective and should further increase the coverage of antiviral therapy.