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抗5-羟色胺类等药物经恶性疟原虫体外培养测定与约氏鼠疟试验初步证明,对红内期无性体疟原虫有一定的对抗作用.为了解此类药物对灵长类动物疟疾感染的作用,进行了以下的研究。 材科与方法 一、实验虫种与动物食蟹猴疟原虫系本所引自越南,在猕猴中保存的虫种,对氯喹敏感。本实验的动物宿主均为在我国广西捕获的健康猕猴,实验前血检疟原虫均阴性,体重2.8～4.5kg。 二、实验感染、治疗与观察从感染食蟹猴疟原虫的种源猴抽血,经静脉接种给健康猴,接种后第3d起血检疟原虫,原虫血症达1％以上时,鼻饲
Anti-serotonin and other drugs by Plasmodium falciparum in vitro culture test and about the first mouse malaria test initially demonstrated that the red-phase clonal malaria parasites have some antagonistic effect in order to understand these drugs for primate malaria infection The role of the following research. Materials and methods First, the experimental insects and animals Cynomolgus malaria parasites derived from Vietnam, the caterpillars preserved in rhesus monkeys, sensitive to chloroquine. The animal hosts in this experiment are all healthy macaques captured in Guangxi, China. Before the experiment, the blood samples were negative for malaria parasite and weighed 2.8-4.5kg. Second, the experimental infection, treatment and observation from the infected cynomolgous macaques monkey blood, intravenous vaccination to healthy monkeys, the blood test three days after inoculation of Plasmodium parasites, parasitemia over 1%, nasal feeding