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在雄性大鼠去势模型上观察了大鼠肝脏生物转化酶活性及抗氧化功能的变化。结果表明，去势大鼠肝和肾上腺指数减小，肝微粒体细胞色素Ｐ４５０含量及谷胱甘肽Ｓ－转移酶活性明显降低，肝匀浆谷胱甘肽减少和丙二醛增加，这些皆呈去势时间依赖性变化。提示雄性大鼠去势后肝脏代谢能力及抗氧化功能的降低可能与雄激素水平低下有关。
The rat liver biotransformation enzyme activity and anti-oxidative function were observed in the castration model of male rats. The results showed that the index of liver and adrenal gland in ovariectomized rats decreased, the content of cytochrome P450 in liver microsomes and glutathione S-transferase activity decreased significantly, and glutathione in liver homogenate decreased and malondialdehyde increased Time-dependent changes in castration. Prompted the male rats after the castration of the liver metabolism and anti-oxidant function may be related to low androgen levels.