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目的探讨血清中封闭抗体(BA)及纤溶酶原激活抑制物-1(PAI-1)水平在自然流产患者中的临床应用价值。方法采用酶联免疫吸附试验、免疫比浊方法对89例自然流产患者以及92例人工流产患者的血清,分别进行BA及PAI-1水平检测。结果与人工流产组比较,自然流产患者BA阳性率显著降低,而PAI-1水平显著增高,差异具有统计学意义(P<0.01,P<0.05);并且自然流产次数≤2次患者,BA阳性率为8%,而自然流产次数≥3次患者BA阳性率显著降低,仅为2%,差异具有统计学意义(P<0.05);PAI-1水平在自然流产次数≤2次患者为(76.43±7.45)ng/ml,而在自然流产次数≥3次患者显著增高为(101.19±13.35)ng/ml,差异具有统计学意义(P<0.01)。结论 BA及PAI-1对自然流产的早期预防、早期诊断及早期积极治疗有着重要的临床应用价值。
Objective To investigate the clinical value of serum blocking antibody (BA) and plasminogen activator inhibitor-1 (PAI-1) levels in patients with spontaneous abortion. Methods Serum levels of BA and PAI-1 in 89 cases of spontaneous abortion and 92 cases of induced abortion were detected by enzyme-linked immunosorbent assay and immunoturbidimetry. Results Compared with the induced abortion group, the positive rate of BA in patients with spontaneous abortion decreased significantly while the level of PAI-1 increased significantly (P <0.01, P <0.05), and those with spontaneous abortion less than or equal to 2 (P <0.05). The rate of PAI-1 in patients with spontaneous abortion ≥ 3 times was significantly lower than that in patients with spontaneous abortion ≥ 2 (76.43%, P <0.05) ± 7.45) ng / ml, while it was significantly higher (101.19 ± 13.35) ng / ml in patients with spontaneous abortion≥3 times. The difference was statistically significant (P <0.01). Conclusions BA and PAI-1 have important clinical value in early prevention, early diagnosis and early aggressive treatment of spontaneous abortion.