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早在一世纪以前,就知道蛋白质可以水解为各个氨基酸,并了解膳食蛋白的增减可影响氮平衡的正负。1889年Neumeister应用酪蛋白的轻度碱水解液于人体输注后,并不出现蛋白尿与毒性反应,但不能维持氮平衡。1913年Henriques等采用肌肉的酶水解液,山静脉输注于山羊,结果可以维持氮平衡。以后,1915年Woodyatt等及1934年Rose均建议静脉输注氨基酸可以作为蛋白质营养。直至1937年Elman首先成功地应用添加色氨酸的酪蛋白酸水解液及酪蛋白酶水解液于临床。1940年Shohl等首先应用一种完全由各个纯氨基酸组成的混合液于临床。这对现代的完全静脉营养的发展奠定了基础。
As early as a century ago, we know that protein can be hydrolyzed to each amino acid, and understand that dietary protein increase or decrease can affect the positive and negative nitrogen balance. 1889 Neumeister casein mild alkaline hydrolyzate infusion in humans, does not appear proteinuria and toxic reactions, but can not maintain the nitrogen balance. In 1913 Henriques and other muscle enzymatic hydrolyzate, mountain vein infusion in goats, the result can maintain nitrogen balance. Later, in 1915 Woodyatt et al. And Rose in 1934 proposed intravenous infusion of amino acids as protein nutrition. Until 1937 Elman first successful application of tryptophan added casein hydrolyzate and casein hydrolyzate in the clinic. In 1940 Shohl et al first applied a purely pure mixture of amino acids in clinical. This laid the foundation for the development of modern complete parenteral nutrition.